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KMID : 1123920030170051270
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 5 p.1270 ~ p.1275
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Effect of Kamihyungbangjihwang-tang on Immediate-type Allergic Reaction
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Kim Kwang-Sik
Lee Dong-Hee
Ko Dae-Woong
Song Jeong-Mo
Eun Jae-Soon
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Abstract
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The purpose of this research was to investigate the effects of Kamihyungbangjihwang-tang (KHT) on immediate-type allergic reaction. KHT was composed of hyungbangjihwangtang (HJT) and Rubus coreanus Miquel (RC) and Aspalathus linear is (AL). KHT and HJT (500 mg/kg) inhibited the systemic anaphylaxis induced by compound 48/80 and inhibited the passive cutaneous anaphylaxis (PCA) induced by anti-dinitrophenyl (DNP)-IgE and DNP-human serum albumin (HSA) in vivo. In addition, KHT, HJT, RC and AL inhibited the release of histamine and increased the release of cAMP from rat peritoneal mast cells. The anti-allergic action of KHT was more potent than those of HJT. These results indicate that KHT may be useful for the prevention and treatment of type I allergy related disease via inhibition of histamine release from mast cells.
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KEYWORD
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Kamihyungbangjihwang-tang(加味荊防地黃湯), Rubus coreanus Miquel, Aspalathus Iinearis, mast cell, histamine, cAMP
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